Stearoyl CoA desaturase 1 (SCD1) and Seipin: Important players in hepatic steatosis?
نویسندگان
چکیده
منابع مشابه
Investigation of (Stearoyl-CoA Desaturase 1) SCD1 Gene Polymorphism in Khuzestan Buffalo Population Using PCR-RFLPMethod
Stearoyl-CoA desaturase (SCD) is a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids (MUFA). A number of studies support the hypothesis that SCD gene regulation and polymorphism may affect fatty acid composition and fat quality in meat and milk. Single nucleotide polymorphisms in the coding region of the bovine stearoyl-CoA desaturase gene have been predicted to result in ...
متن کاملinvestigation of (stearoyl-coa desaturase 1) scd1 gene polymorphism in khuzestan buffalo population using pcr-rflpmethod
stearoyl-coa desaturase (scd) is a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids (mufa). a number of studies support the hypothesis that scd gene regulation and polymorphism may affect fatty acid composition and fat quality in meat and milk. single nucleotide polymorphisms in the coding region of the bovine stearoyl-coa desaturase gene have been predicted to result in ...
متن کاملInhibition of Stearoyl-CoA Desaturase 1 (SCD1) DissociatesInsulin Resistance and Obesity From Atherosclerosis
Background—Stearoyl-CoA Desaturase 1 (SCD1) is a well-known enhancer of the metabolic syndrome. The purpose of the present study was to investigate the role of SCD1 in lipoprotein metabolism and atherosclerosis progression. Methods and Results—Antisense oligonucleotides were used to inhibit SCD1 in a mouse model of hyperlipidemia and atherosclerosis (LDLr-/-Apob100/100). In agreement with previ...
متن کاملAryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis.
2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD) induces hepatic dyslipidemia mediated by the aryl hydrocarbon receptor (AhR). Stearoyl-CoA desaturase 1 (Scd1) performs the rate-limiting step in monounsaturated fatty acid (MUFA) synthesis, desaturating 16:0 and 18:0 into 16:1n7 and 18:1n9, respectively. To further examine the role of Scd1 in TCDD-induced hepatotoxicity, comparative studies were perfo...
متن کاملSignificant associations of stearoyl-CoA desaturase (SCD1) gene with fat deposition and composition in skeletal muscle
Gene expression studies in humans and animals have shown that elevated stearoyl-CoA desaturase (SCD1) activity is associated with increased fat accumulation and monounsaturation of saturated fatty acids in skeletal muscle. However, results of the two reported association studies in humans are inconsistent. In the present study, we annotated the bovine SCD1 gene and identified 3 single nucleotid...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.813.1